SS-31

SS-31 is primarily being investigated for its potential therapeutic use in diseases and conditions involving mitochondrial dysfunction, including:

1. Age-related diseases

2. Heart disease (e.g., ischemia-reperfusion injury, heart failure)

3. Neurodegenerative diseases (e.g., Alzheimer's, Parkinson's)

4. Kidney disease (especially acute kidney injury and diabetic nephropathy)

5. Muscle weakness and mitochondrial myopathies

6. Eye diseases like dry age-related macular degeneration (AMD)

7. Sepsis and critical illness

What Has Research Shown?

✅ Mechanism of Action:

• SS-31 targets the inner mitochondrial membrane, specifically binding to cardiolipin, a phospholipid essential for mitochondrial function.

• It helps reduce oxidative stress, improves ATP production, and stabilizes mitochondrial structure.

🧪 Key Findings from Research:

1. Mitochondrial Protection

   • Enhances mitochondrial efficiency.

   • Reduces reactive oxygen species (ROS).

   • Prevents apoptosis (cell death) in stressed cells.

2. Cardiovascular Benefits

   • In animal models, SS-31 reduced damage after heart attacks.

   • In early human trials, it showed potential in improving left ventricular function in heart failure patients.

3. Kidney Protection

   • Reduced acute kidney injury in both animal models and limited human studies.

4. Muscle Function

   • Improved exercise tolerance and muscle bioenergetics in aging mice.

   • Studied in mitochondrial myopathy patients with promising but not conclusive results.

5. Eye Health (Dry AMD)

   • A topical form (MTP-131) showed potential in improving visual function in early human studies.

6. Neuroprotection

   • In preclinical models, SS-31 showed potential in protecting neurons and reducing cognitive decline.

⚠️ Current Status

• Not FDA-approved for general clinical use.

• Still in clinical trials for several conditions (e.g., heart failure, dry AMD, mitochondrial diseases).

• Some people use it off-label or experimentally, but long-term safety and effectiveness in humans are still under investigation.

Click Here to view our master database of 3rd-party testing data.

Research-Only Use:

The products offered on this website are intended exclusively for in-vitro laboratory research and development purposes. They are not intended for use as drugs, food additives, cosmetics, household chemicals, or for any form of human or animal consumption, diagnostic, or therapeutic use. No claims are made regarding safety or efficacy in any clinical application.

Disclaimer:

All information provided is for educational and scientific reference only. Statements have not been evaluated by the FDA or any medical regulatory body. This product is not a drug or supplement. Buyer assumes all responsibility for lawful use and compliance with applicable regulations.

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